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U.S. woman recovering well after receiving experimental pig kidney transplant

Towana Looney香蕉视频直播檚 remaining kidney failed after previously donating a kidney to her mom
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The gene-edited pig kidney moments after blood vessels are reattached and the organ is reperfused with Towana Looney香蕉视频直播檚 blood at NYU Langone Health in New York City on Nov. 25, 2024. (Joe Carrotta/NYU Langone Health via AP)

An Alabama woman is recovering well after a last month that freed her from eight years of dialysis, the latest effort to save human lives with animal organs.

Towana Looney is the given a 香蕉视频直播 and notably, she isn香蕉视频直播檛 as sick as who died within of receiving a pig kidney or heart.

香蕉视频直播淚t香蕉视频直播檚 like a new beginning,香蕉视频直播 Looney, 53, told The Associated Press. Right away, 香蕉视频直播渢he energy I had was amazing. To have a working kidney 香蕉视频直播 and to feel it 香蕉视频直播 is unbelievable.香蕉视频直播

Looney香蕉视频直播檚 surgery marks an important step as scientists get ready for formal studies of xenotransplantation expected to begin next year, said Dr. Robert Montgomery of NYU Langone Health, who led the highly experimental procedure.

Looney is recuperating well after her transplant, which was announced Tuesday. She was discharged from the hospital just 11 days after surgery to continue recovery in a nearby apartment although temporarily readmitted this week while her medications are adjusted. Doctors expect her to return home to Alabama in three months. If the pig kidney were to fail, she could begin dialysis again.

香蕉视频直播淭o see hope restored to her and her family is extraordinary,香蕉视频直播 said Dr. Jayme Locke, Looney香蕉视频直播檚 original surgeon who secured Food and Drug Administration permission for the Nov. 25 transplant.

More than 100,000 people are on the U.S. transplant list, most who need a kidney. Thousands die waiting and many more who need a transplant never qualify. Now, searching for an alternate supply, scientists are genetically altering pigs so their organs are more humanlike.

Looney donated a kidney to her mother in 1999. Later a complication during pregnancy caused high blood pressure that damaged her remaining kidney, which eventually failed. It香蕉视频直播檚 incredibly rare for living donors to develop kidney failure although those who do are given extra priority on the transplant list.

But Looney couldn香蕉视频直播檛 get a match 香蕉视频直播 she had developed antibodies abnormally primed to attack another human kidney. Tests showed she香蕉视频直播檇 reject every kidney donors have offered.

Then Looney heard about pig kidney research at t and told Locke, at the time a UAB transplant surgeon, she香蕉视频直播檇 like to try one. In April 2023, Locke filed an FDA application seeking an emergency experiment, under rules for people like Looney who are out of options.

The FDA didn香蕉视频直播檛 agree right away. Instead, the world香蕉视频直播檚 first gene-edited pig kidney transplants went to two sicker patients last spring, at Massachusetts General Hospital and NYU. Both also had serious heart disease. The Boston patient recovered enough to spend about a month at home before dying of sudden cardiac arrest deemed unrelated to the pig kidney. NYU香蕉视频直播檚 patient had heart complications that damaged her pig kidney, forcing its removal, and she later died.

Those disappointing outcomes didn香蕉视频直播檛 dissuade Looney, who was starting to feel worse on dialysis but, Locke said, hadn香蕉视频直播檛 developed heart disease or other complications. The FDA eventually allowed her transplant at NYU, where Locke collaborated with Montgomery.

Even if her new organ fails, doctors can learn from it, Looney told the AP: 香蕉视频直播淵ou don香蕉视频直播檛 know if it香蕉视频直播檚 going to work or not until you try.香蕉视频直播

Blacksburg, Virginia-based Revivicor provided Looney香蕉视频直播檚 new kidney from a pig with 10 gene alterations. Moments after Montgomery sewed it into place, the kidney turned a healthy pink and began producing urine.

Looney was initially discharged on Dec. 6, wearing monitors to track her blood pressure, heart rate and other bodily functions and returning to the hospital for daily checkups before her medication readmission. Doctors scrutinize her bloodwork and other tests, comparing them to prior research in animals and in hopes of spotting an early warning if problems crop up.

香蕉视频直播淎 lot of what we香蕉视频直播檙e seeing, we香蕉视频直播檙e seeing for the first time,香蕉视频直播 Montgomery said.

During a visit last week with Locke, who now works for the federal government, Looney hugged her longtime doctor, saying, 香蕉视频直播淭hank you for not giving up on me.香蕉视频直播

香蕉视频直播淣ever,香蕉视频直播 Locke responded.





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